这篇文章利用狂犬病毒介导的逆行追踪技术，对胶质母细胞瘤（GB）的神经元-肿瘤网络进行了深入研究，揭示了GB细胞快速整合到神经回路中，从而促进其侵袭和生长。研究表明，这种整合发生在疾病的早期阶段，并且涉及胆碱能和谷氨酸能神经元等多种神经元群体。关键发现包括乙酰胆碱介导的肿瘤生长以及放射疗法增加神经元活动和连接。此外，文章提出了靶向神经元-肿瘤网络的治疗潜力，包括使用药物断开连接或通过狂犬病毒介导的基因消融来抑制肿瘤进展。References: Tetzlaff S K, Reyhan E, Layer N, et al. Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing[J]. Cell, 2025, 188(2): 390-411. e36.
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