这篇文章介绍了一项名为“免疫词典”的大规模研究，该研究利用单细胞转录组测序技术，系统性地描绘了小鼠淋巴结中超过17种免疫细胞类型对86种细胞因子的反应概况。研究发现，大多数细胞因子诱导高度细胞类型特异性的基因表达变化和细胞极化状态，揭示了免疫细胞惊人的可塑性和细胞因子网络的复杂性。基于此“免疫词典”，研究人员开发了配套软件“免疫反应富集分析（IREA，该软件能够从基因表达数据中推断细胞因子活性、免疫细胞极化状态以及细胞间通讯网络，并成功应用于分析肿瘤免疫治疗和严重COVID-19感染等复杂免疫反应数据。References: Cui A, Huang T, Li S, et al. Dictionary of immune responses to cytokines at single-cell resolution[J]. Nature, 2024, 625(7994): 377-384.
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