Description
这篇文章讨论了癌症治疗中的药物耐药性这一复杂问题，指出它是实现癌症治愈的主要限制因素。作者首先通过还原论方法确定并分离了耐药性的关键决定因素，包括肿瘤负荷和生长动力学、肿瘤异质性、物理屏障、免疫系统和微环境，以及治疗压力带来的后果。文章接着提出了四种主要的解决方案，旨在通过早期检测、实现更深层次的治疗反应、进行治疗监测和自适应干预，以及利用癌症依赖性来克服或延迟耐药性的出现。最终，文章展望了将工程学和癌症生物学结合起来，以制定实时临床决策，最终战胜癌症耐药性的前景。References: Vasan N, Baselga J, Hyman D M. A view on drug resistance in cancer[J]. Nature, 2019, 575(7782): 299-309.
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