这篇文章提供了一篇关于自然杀伤（NK）细胞疗法的全面综述，重点介绍了其在癌症免疫治疗中的应用和潜力。文章详细探讨了NK细胞的生物学特性，包括其作为先天免疫系统淋巴细胞的能力，以及识别和清除受压细胞（尤其是肿瘤细胞和受病毒感染细胞）的功能。它还分析了NK细胞治疗的各种策略，包括使用免疫检查点抑制剂、NK细胞衔接器（NKCEs），以及输注经过预活化或基因工程改造的自体或异体NK细胞产品。最后，该综述强调了NK细胞疗法在治疗血液系统恶性肿瘤方面取得的进展，并指出了优化其对实体瘤的疗效所面临的挑战和未来方向。References: Vivier E, Rebuffet L, Narni-Mancinelli E, et al. Natural killer cell therapies[J]. Nature, 2024, 626(8000): 727-736.
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