这篇文章深入探讨了线粒体的内共生起源如何使其成为细胞内信号传导的关键枢纽，特别是与炎症和免疫反应相关联。文章指出，线粒体保留的细菌特征（如未甲基化的DNA和某些蛋白质）通常被细胞隔离，但当这种内共生关系破裂时，这些线粒体因子释放到细胞质中，就会触发免疫反应和炎症。文章提出了一个中心假说：环境因素（如肥胖和饮食变化）引起的线粒体功能障碍和信号失调，可能是炎症和自身免疫性疾病发病率上升的关键原因，从而为开发新的治疗方法提供了理论基础。References: Murphy M P, O’Neill L A J. A break in mitochondrial endosymbiosis as a basis for inflammatory diseases[J]. Nature, 2024, 626(7998): 271-279.
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