Description
这篇评论文章深入探讨了干扰素 (IFN) 在健康和疾病中的基本作用，干扰素是具有保护和致病作用的信号蛋白。文章详细介绍了I 型、II 型和 III 型干扰素的结构、功能和受体，尽管它们不同，但都通过 Janus 激酶网络进行信号传导。作者概述了调控 IFN 诱导和反应的细胞和分子机制，强调了它们在感染、肿瘤发生、自身免疫、炎症和遗传疾病中的作用，特别是在粘膜组织中。总体而言，该文本侧重于平衡的 IFN 家族成员产生对于保护功能至关重要，而这种平衡的丧失可能导致各种病理后果，包括被称为干扰素病的疾病。References: Boehmer D, Zanoni I. Interferons in health and disease[J]. Cell, 2025, 188(17): 4480-4504.
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