这篇文章介绍了名为 Stereo-seq V2 的先进空间转录组学技术。该技术专为对福尔马林固定、石蜡包埋 (FFPE) 样本进行高分辨率总RNA空间定位而设计，这些样本是临床实践中常见但难以进行高质量 RNA 分析的样本。Stereo-seq V2采用随机引物捕获策略，与仅针对聚腺苷酸（poly(A)）尾巴的技术相比，能够实现无偏性转录本捕获和全基因体覆盖，从而能更有效地分析非编码 RNA (ncRNA) 和免疫受体库。这项创新使得该技术能够同时分析宿主和病原体的转录组，并在三阴性乳腺癌 (TNBC) 和结核病 (TB) 患者的临床FFPE样本中，以单细胞分辨率识别肿瘤相关剪接事件和空间免疫克隆动态。研究结果强调了Stereo-seq V2在生物医学研究和 个性化医疗 中的巨大潜力。References: Zhao Y, Li Y, He Y, et al. Stereo-seq V2: Spatial mapping of total RNA on FFPE sections with high resolution[J]. Cell, 2025.
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