这篇文章详细介绍了一项基于成像质谱流式细胞术 (IMC) 对三阴性乳腺癌（TNBC）肿瘤的空间单细胞图谱分析研究。作者通过识别基底腔细胞表型和CD8+ T 细胞空间相互作用模式，建立了一种新的乳腺癌分层系统，旨在提高对疾病复发风险的预测。研究发现，具有干细胞样特征的基底腔肿瘤细胞（表达 CK5 和 CK7）与疾病快速复发相关，而具有炎症性 CD8+ T 细胞环境的肿瘤则预示着更好的预后和免疫治疗响应率。最终，该研究整合这些特征提出了五种乳腺癌亚型和三种风险组，为 TNBC 的临床分型和治疗提供了新的指导方向。References: Meyer L, Jackson H W, Eling N, et al. A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture[J]. Cancer Cell, 2025, 43(9): 1637-1655. e9.
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