这篇文章介绍并验证了 PathoPlex，这是一个可扩展且可解释的框架，用于在亚细胞分辨率下对甲醛固定石蜡包埋 (FFPE) 标本进行 高多重成像。PathoPlex 结合了基于循环免疫荧光成像 的通用实验方案和spatiomic这一开源软件库，后者专注于像素级蛋白质共表达模式分析。该方法旨在克服现有空间生物学技术的局限性，例如设备依赖性、抗体组大小限制以及空间分辨率不足，提供了一个无需商业设备且具备自动化功能的解决方案。通过对肾脏疾病（包括小鼠模型和人类糖尿病肾病）的应用，该研究展示了PathoPlex在识别与疾病相关的生物学特征方面的效用，并将其用于药物和生物标志物的发现。References: Kuehl M, Okabayashi Y, Wong M N, et al. Pathology-oriented multiplexing enables integrative disease mapping[J]. Nature, 2025: 1-11.
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