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聊聊Sci

138-神经元线粒体驱动癌细胞扩散

07 Oct 2025

Description

这份研究概述了癌症神经科学这一新兴领域,强调了神经元在癌症的发生、生长和扩散中的作用。文章重点介绍了线粒体这一细胞器在细胞间的转移现象,它能够为癌细胞提供能量并改变其代谢方式。具体来说,研究人员利用一种名为 MitoTRACER 的追踪工具,发现在乳腺癌、黑色素瘤和前列腺癌等多种癌症类型中,神经元会将线粒体通过隧道纳米管转移给癌细胞。这种转移促使癌细胞进行代谢重编程,增强了其氧化呼吸能力、干性和锚定非依赖性生长,最终驱动了癌症向远端部位的扩散。References: Mitochondria exit neuronsand drive cancer spread

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