这篇篇科学论文重点研究了癌症引起的神经损伤 (CINI)如何促进肿瘤对抗 PD-1 疗法产生抗性。研究人员通过对皮肤鳞状细胞癌 (cSCC)、黑色素瘤和胃癌患者队列的多组学分析和临床试验数据，结合体内小鼠模型和体外细胞共培养实验，提出了一个机制。这一机制表明癌细胞通过髓磷脂降解导致神经损伤，进而触发神经炎症，上调 IFN-I 和 IL-6 信号通路，最终在肿瘤微环境中形成免疫抑制环境。实验结果表明，通过阻断 IFN-I 或 IL-6 信号传导可以逆转免疫抑制，从而恢复抗 PD-1 治疗的有效性。References: Baruch E N, Gleber-Netto F O, Nagarajan P, et al. Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy[J]. Nature, 2025: 1-12.
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