这项研究综合运用了单细胞RNA测序和空间转录组分析，以深入了解垂体神经内分泌肿瘤（PitNETs）的异质性及其进展机制。研究人员分析了超过177,000个细胞和35,000个位点，识别出不同的肿瘤细胞群，并详细描述了肿瘤微环境（TME）在肿瘤侵袭和进展过程中的重构。具体而言，该研究揭示了TPIT谱系PitNETs的侵袭性肿瘤集群，该集群以p53介导的增殖增加和更高的Trouillas分级为特征。此外，研究还发现SPP1+肿瘤相关巨噬细胞（TAMs）在侵袭性肿瘤中富集，并通过SPP1-ITGAV/ITGB1信号通路促进肿瘤侵袭。这些发现不仅揭示了PitNETs TME中的分子动态，还为潜在的治疗靶点提供了线索。References: Su W, Ye Z, Liu J, et al. Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progression[J]. Nature Communications, 2025, 16(1): 5007.
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