Description
这篇综述讨论了嵌合抗原受体T细胞（CAR-T）疗法在治疗实体瘤方面所面临的挑战和最新进展。文章指出，尽管CAR-T疗法在血液系统恶性肿瘤中取得了显著成功，但在实体瘤中的应用受限于抗原异质性和免疫抑制性肿瘤微环境（TME）等因素。为了增强疗效，综述探索了多种策略，例如提高T细胞的持久性和细胞毒性、靶向多种抗原以及结合免疫检查点抑制剂等。此外，文章还概述了针对肺癌、肝细胞癌、胃癌和胶质瘤等多种实体瘤的临床试验结果，并展望了通过基因编辑和新型CAR设计等技术克服障碍的未来前景。References: Du B, Qin J, Lin B, et al. CAR-T therapy in solid tumors[J]. Cancer Cell, 2025, 43(4): 665-679.
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