这篇文章报告了一项多组学研究，旨在找出导致非小细胞肺癌患者对免疫检查点抑制剂联合化疗产生抵抗的因素。通过分析大量的单细胞转录组和空间转录组数据，研究人员在肿瘤微环境中发现了胶原蛋白XI α 1链阳性（COL11A1+）癌症相关成纤维细胞和分泌型磷蛋白1阳性（SPP1+）巨噬细胞之间的相互作用。这种相互作用会导致肿瘤边界胶原纤维沉积，从而阻碍T细胞浸润，预示着较差的预后。此外，研究还揭示了三级淋巴结构（TLSs）的不同成熟阶段，其中激活的TLSs与改善预后相关，而缺氧环境则可能抑制TLSs的发展并导致预后不佳。References: Yan Y, Sun D, Hu J, et al. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer[J]. Nature Genetics, 2025, 57(1): 126-139.
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