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聊聊Sci

163-树突纳米管网络与阿尔茨海默病

20 Oct 2025

Description

这篇Science文章介绍了一种神经元之间新的非突触通信机制,即树突纳米管 (DNT) 网络,挑战了传统上认为神经元主要通过突触进行通信的观点。研究人员利用先进的显微镜技术在小鼠和人类大脑组织中识别出这些由树突丝状伪足形成的、含有肌动蛋白的细长膜桥,它们能够介导钙信号和大分子(如淀粉样蛋白 Aβ)在神经元之间的远距离传输。重要的是,该研究表明,在阿尔茨海默病 (AD) 的早期病理阶段,DNT 网络的形成和功能发生变化,并且计算模型预测这种异常连接的增加可能会加速有毒 Aβ 在特定神经元内的累积,从而为AD的传播机制提供了一个新的见解。References: Chang M, Krüssel S, Parajuli L K, et al. Intercellular communication in the brain through a dendritic nanotubular network[J]. Science, 2025, 390(6768): eadr7403.

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