这篇文章概述了一项关于转移性胰腺导管腺癌 (PDAC) 空间转录组可塑性的研究，该研究使用了从 13 名患者的原发性肿瘤和多器官转移灶（肝、肺和腹膜）的快速尸检中收集的样本。研究人员构建了肿瘤细胞谱系状态、克隆结构和肿瘤微环境 (TME) 的高分辨率图谱，揭示了肿瘤从原发部位到特定器官转移灶过程中发生的转录组学差异。主要发现包括不同转移灶（尤其是肝脏和肺部）之间的显著转录组差异、患者特异性的克隆演化轨迹，以及“基底样”癌细胞与肌成纤维细胞样癌症相关成纤维细胞 (myCAFs) 之间的空间共定位。这些 myCAFs 似乎通过 CXCL12–CXCR4 信号通路促使浆细胞排除在肿瘤环境之外，强调了转移性 PDAC 中谱系状态、TME 组成和免疫抑制之间的复杂关系。References: Pei G, Min J, Rajapakshe K I, et al. Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer[J]. Nature, 2025: 1-10.
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