这份研究探究了干扰素-γ（IFNγ）在软脑膜转移（LM）中的抗肿瘤作用。文章表明，LM是实体瘤的一种致命并发症，涉及脑脊液（CSF）中强烈的炎症反应。研究人员利用人体临床样本和免疫功能完善的小鼠模型发现，T细胞产生的IFNγ是限制肿瘤生长的关键调节因子。他们进一步阐明，IFNγ并非直接作用于癌细胞，而是通过作用于树突状细胞（DCs），促进其成熟为CCR7+ DCs，这些成熟的DC随后产生IL-12和IL-15等细胞因子，从而支持自然杀伤（NK）细胞的增殖和细胞毒性作用，最终控制软脑膜中的肿瘤扩展。研究人员总结道，这种不依赖于适应性免疫和抗原呈递的抗肿瘤反应，为针对LM的免疫治疗提供了独特的新靶点。References: Remsik J, Tong X, Kunes R Z, et al. Interferon-γ orchestrates leptomeningeal anti-tumour response[J]. Nature, 2025: 1-10.
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