这篇文章介绍了研究人员如何系统性地表征健康组织中的跨组织协调细胞模块（CMs），并通过开发名为CoVarNet的计算框架来分析这些模块。通过汇编包含来自35个人体组织的超过200万个细胞的综合单细胞转录组图谱，该研究确定了12个具有独特细胞组成和组织偏好的CMs。文章利用空间转录组学和细胞通讯分析来验证CMs的空间组织和细胞间通信。此外，该研究还探究了CMs在衰老、更年期和癌症中的动态变化，发现在肿瘤进展过程中，组织特异性健康组织结构会丧失，并出现趋同的癌性生态系统。这些发现揭示了健康与疾病中多细胞生态系统的基本组织原则。References: Shi Q, Chen Y, Li Y, et al. Cross-tissue multicellular coordination and its rewiring in cancer[J]. Nature, 2025: 1-10.
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