这篇文章探讨了将髓系细胞（特别是巨噬细胞）工程化用于癌症免疫治疗的潜力。文章主要围绕嵌合抗原受体巨噬细胞（CAR-M）展开，将其作为克服当前CAR-T细胞疗法局限性的一种有前景的策略。作者评估了CAR-M的安全性、抗肿瘤活性以及在实体瘤中的浸润能力，指出CAR-M相较于CAR-T细胞具有更低的细胞因子释放综合征和神经毒性风险。此外，文章强调了CAR-M在调节肿瘤微环境和诱导内源性抗肿瘤T细胞反应方面的独特优势，并讨论了通过优化CAR构建和体内基因编辑来提高CAR-M疗效和可及性的未来研究方向。References: Chen J, Zhao Y, Chen X, et al. Engineering myeloid cells for cancer immunotherapy[J]. Cancer Cell, 2025, 43(9): 1593-1597.
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