这篇文章报道了泛癌蛋白组图谱 (TPCPA) 的创建，这是一个基于高通量、单次数据非依赖性采集 (DIA) 质谱的大规模蛋白组景观，涵盖了22种癌症类型（包括18种实体瘤和4种血液肿瘤），共计 999 个人类样本。研究旨在通过分析9,670种蛋白质，揭示泛癌生物学、潜在的生物标志物和治疗靶点，例如鉴定出具有预后价值的结直肠癌 (CRC) 免疫亚型，并开发了一个用于识别原发不明转移瘤的多癌分类器。所有TPCPA数据 均可通过专门的网络资源进行查询。References: Knol J C, Lyu M, Böttger F, et al. The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets[J]. Cancer Cell, 2025.
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