这份研究概述了一项关于肉瘤样肾细胞癌 (sRCC) 复杂肿瘤免疫微环境的全面研究，这种癌症类型虽然侵袭性极高，但对免疫检查点阻断疗法 (ICB) 却表现出异常的敏感性。文章通过单细胞和空间分析，揭示了sRCC中T细胞的活化和衰竭状态增加，以及三级淋巴结构 (TLS) 的普遍存在。研究进一步证明，sRCC 中B细胞成熟和抗肿瘤体液免疫活动增强，同时还发现了一个与铁代谢相关的潜在脆弱性。最重要的是，作者们提出了一个“基因组去分化特征 (GDS)”转录组特征，该特征虽然预示着较差的预后，但在多个队列和肿瘤类型中都可预测患者对ICB治疗的积极反应。References: Salgia N J, Khan A, Aubrecht W M, et al. Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma[J]. Cancer Cell, 2025.
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