这篇文章详细介绍了利用多模式分析框架对人头颈部鳞状细胞癌（HNSCC）中T细胞的克隆性、表型和空间定位进行单细胞分辨率分析。研究人员整合了高维流式细胞术、单细胞RNA和TCR测序以及空间转录组学，特别是空间解析的TCR谱分析，以揭示T细胞在肿瘤微环境（TME）中的组织原理。关键发现包括T细胞表型（如干细胞样或耗竭状态）与其空间位置（如富含免疫的生态位或肿瘤密集区域）之间存在关联，表明局部环境线索而非仅克隆身份决定了T细胞的功能和分化。该研究还建立了一个通用平台，用于在实体瘤中进行空间解析的、抗原特异性T细胞谱分析。References: McCord K A, Kan E, Hyslop S, et al. Single-cell, Spatially-Resolved TCR Profiling Links T Cell Phenotype and Clonality in Human Tumors[J]. BioRxiv, 2025: 2025.08. 06.668925.
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