这篇文章详述了一项针对肿瘤相关三级淋巴结构 (TA-TLSs) 的泛癌症空间转录组学研究，旨在解析其细胞特征、空间组织和成熟机制。研究团队通过分析不同成熟阶段（淋巴聚集体、原发滤泡样和继发滤泡样）的TA-TLSs，发现IgG + 浆细胞在成熟的TA-TLSs中富集。他们识别出 CCL19 + 血管周细胞可能作为淋巴组织组织者细胞，促进TA-TLSs的形成，并通过实验证明动脉内皮细胞能够获得高内皮微静脉（HEV）样表型，这与Notch信号通路的抑制有关。这些发现全面剖析了TA-TLSs的细胞组成，并提出了潜在的治疗靶点，旨在将免疫冷的肿瘤转化为免疫原性肿瘤。References: Li X, Chu X, Xu W, et al. Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures[J]. Cell Reports, 2025, 44(9).
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