这篇文章利用长读长单细胞核RNA测序（snNanoRNAseq）技术，全面绘制了成年人心脏及其衰竭状态下的剪接异构体图谱。研究人员深入分析了健康和心力衰竭（HF）患者左心室中不同细胞类型（尤其是心肌细胞）的全长异构体异质性和使用模式。核心发现是，异构体多样性在心脏细胞系统中普遍存在，不仅作为一种转录后缓冲系统来校准分子储备，而且在心力衰竭中，许多基因表现出显著的差异异构体使用（DIU）变化，这些变化通常会改变蛋白质编码结果，揭示了剪接调控在心脏疾病发病机制中的关键作用。这些详细的细胞特异性异构体数据作为一个重要的参考资源，有助于未来的转化和机制研究，并通过一个在线数据门户供公众查阅。References: Pan T, Lu L, Youker K, et al. Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure[J]. Circulation, 2025.
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