这份研究文章总结主要介绍了脂肪组织巨噬细胞（ATMs）的亚组织定位与其功能的关系，特别聚焦于分隔巨噬细胞（sATMs）。研究人员确定了三种不同的ATM群组——实质性（pATMs）、囊性（cATMs）和分隔性（sATMs），并发现sATMs（由CD209b和LYVE1标记）驻留在白色脂肪组织（WAT）的间隔中，靠近脂肪细胞干细胞（ASCs）。通过转化生长因子-β1 (TGFβ1) 信号传导，这些sATMs指导ASCs分化为储存能量的白色脂肪细胞，从而限制产热潜力。实验证明，去除或功能性失活sATMs会使ASCs转向米色脂肪生成，增强能量消耗，并预防饮食诱导的肥胖和胰岛素抵抗，这表明靶向sATM–TGFβ1–ASC轴可能是一种治疗代谢性疾病的策略。References： Yu X, Hu Y, Lim H Y, et al. Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential[J]. Science, 2025, 389(6763): eadg1128.
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