这篇文章重点研究OTX2-PAX3 信号轴如何调控第 3 组髓母细胞瘤的细胞命运。研究表明，OTX2 是一种强效癌基因，通过抑制神经分化和调控染色质结构来促进肿瘤生长，而PAX3 和 PAX6的低表达与患者生存率降低相关。文章通过多组学和体外体内实验发现，OTX2 沉默会增加 PAX3 表达并降低 mTORC1 信号活性，PAX3 的过表达也能显著抑制肿瘤发生和延长生存期。这些发现提示，mTORC1 信号通路与未分化的干细胞/祖细胞程序相关，且可能是治疗这种高侵袭性儿童脑瘤的潜在靶点。References: Zagozewski J, Shahriary G M, Morrison L C, et al. An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate[J]. Nature Communications, 2020, 11(1): 3627.
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