这篇综述文章重点介绍了髓母细胞瘤（MB），这是一种常见的儿童中枢神经系统恶性肿瘤。文章概述了自首次下一代测序研究以来，通过大规模基因组学、表观基因组学、转录组学和蛋白质组学分析所获得的分子和生物学见解，详细阐述了MB的四种公认分子亚组（WNT、SHH、Group 3 和 Group 4）及其进一步细分。此外，它探讨了肿瘤内异质性、复发和转移的分子机制，并讨论了这些分子发现如何转化为改进的风险分层和分子靶向治疗等新兴临床应用，强调了进行细致的临床前和分子测试的重要性。References: Hovestadt, Volker, et al. "Medulloblastomics revisited: biological and clinical insights from thousands of patients." Nature Reviews Cancer 20.1 (2020): 42-56.
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