这篇综述文章探讨了 RNA 剪接失调与癌症特征之间的密切关系。文章详细解释了异常剪接如何成为几乎所有肿瘤类型的分子特征，这种改变源于复发性突变和反式作用因子表达的改变，从而促进肿瘤发生。作者随后讨论了异常剪接如何通过影响细胞增殖、凋亡、转移、化疗抵抗和免疫逃逸等“癌症的标志”来驱动癌症发展。最后，文章回顾了针对剪接机制（如SF3B1 抑制剂和剪接因子靶向）以及特定剪接异构体（如利用反义寡核苷酸）的现有和新兴癌症治疗方法。References: Bradley, Robert K., and Olga Anczuków. "RNA splicing dysregulation and the hallmarks of cancer." Nature Reviews Cancer 23.3 (2023): 135-155.
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