Description
这份研究利用基于抗体的空间蛋白质组学和3D共聚焦成像技术，对人类初级纤毛的715种蛋白质进行了定位，揭示了初级纤毛在不同细胞类型和单个纤毛中存在的广泛异质性。研究发现了纤毛内的空间微域，确定了69%的纤毛蛋白具有细胞类型特异性，并确认了91种新型纤毛蛋白，其中CREB3被认为是纤毛病候选基因。该研究最终建立了一个开放的、具有空间信息的纤毛图谱，以促进纤毛和纤毛病的研究。References: Hansen, Jan N., et al. "Intrinsic heterogeneity of primary cilia revealed through spatial proteomics." Cell (2024).
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