这篇文章深入研究了星形胶质细胞的超微结构及其与神经元突触的相互作用，超越了传统的“三方突触”概念，提出了“三方突触网络”的新模型。研究使用聚焦离子束/扫描电子显微镜 (FIB-SEM)和双光子钙成像技术，揭示了星形胶质细胞的“小叶”（leaflets）区域通过缝隙连接形成相互连接的结构域，并富含表达IP3受体的微小内质网（i-ER）。这些小叶域能够整合来自多个独立突触回路的信号，并响应突触活动产生依赖于IP3R1的钙信号，表明星形胶质细胞在神经信息处理中起着时空整合和协调者的作用。References: Benoit, Lucas, et al. "Astrocytes functionally integrate multiple synapses via specialized leaflet domains." Cell (2025).
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