这篇文章研究了 IL-25 诱导的 2 型天然淋巴细胞（ILC2s） 如何在小肠中建立并维持长期的 粘膜免疫。研究人员发现，IL-25 治疗能够导致小肠的持续适应性变化，这种适应性是通过具有 效应记忆特性 的 ILC2s 来维持的。这些 效应记忆 ILC2s 与增强对各种粘膜病原体的抵抗力有关，并且在 没有警报素（alarmins）或 簇状细胞（tuft cells）的情况下依然能保持其激活状态和功能。通过单细胞 RNA 测序和 ATAC 测序，文章揭示了这些 ILC2s 具有独特的 转录和表观遗传特征，并证明了它们在保护宿主免受蠕虫和细菌感染中的关键作用。References: Cortez, Victor S., et al. "IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity." Cell (2025).
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