这篇研究探讨了肿瘤微环境（TME）中细菌的作用，特别是具核梭杆菌（Fusobacterium nucleatum）如何影响癌细胞的行为。通过结合人类肿瘤的空间成像和单细胞空间转录组学、3D共培养以及小鼠模型，研究发现细胞外细菌会破坏癌上皮细胞间的连接，诱导细胞进入静止状态（G0-G1期停滞）。这种细菌诱导的静止状态降低了癌细胞对化疗药物（如5-FU）的敏感性，从而提供了具核梭杆菌与结直肠癌（CRC）复发和不良病理反应相关联的机制性见解。总体而言，该研究揭示了细胞外细菌是TME中一个关键的、具有空间组织的组成部分，可作为癌症治疗的新靶点。References: Niño, Jorge Luis Galeano, et al. "Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest." Cancer Cell (2025).
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