这份研究探讨了 T 细胞免疫监视在预防肉瘤早期发生中的作用。作者使用荧光新抗原标记的自生性小鼠肉瘤模型，发现 T 细胞显著降低了肿瘤的穿透率和发生时间。研究表明，T 细胞通过干扰素-γ（IFNγ）非依赖性机制清除表达新抗原的癌细胞，并通过 IFNγ 依赖性旁观者效应消除邻近的非免疫原性癌细胞，从而实现对新生肉瘤的有效免疫编辑。这些发现揭示了 T 细胞在肿瘤早期消除免疫原性和非免疫原性细胞方面所起的双重作用，解释了肿瘤穿透率降低的机制。References: Cheung, Julie F., et al. "Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas." Cancer Cell (2025).
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