这篇文章探讨了胶质母细胞瘤（GBM）的空间结构如何影响其细胞特性。作者利用单细胞分辨率空间转录组学研究了 GBM 肿瘤，发现癌细胞组织成同型簇（homotypic clusters）时，其细胞特性保持稳定（locks tumor cell identity），而分散的细胞（dispersed cells）则表现出更强的可塑性（plasticity），并与更差的预后相关。该研究进一步揭示，同型聚集和分散是癌症细胞的一般特征，并通过实验模型验证了细胞粘附机制是维持聚集和抑制可塑性的关键。References: Migliozzi, Simona, et al. "Restraint of cancer cell plasticity by spatial homotypic clustering." Cancer cell (2025).
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