这篇文章详细介绍了癌细胞如何利用器官间的神经免疫回路来逃避免疫监视，特别是针对头颈部鳞状细胞癌（HNSCC）患者的临床数据以及小鼠口腔癌模型进行研究。研究表明，癌细胞在免疫压力下会分泌一种配体（SLIT2），通过触发肿瘤相关巨噬细胞（TAMs）的内质网应激反应，激活伤害感受性神经元，从而在引流淋巴结（TDLNs）中建立免疫抑制环境。通过光遗传学和化学遗传学等方法，该研究还证实了抑制伤害感受性神经元的活动可以重塑TDLNs的免疫状态，增强抗肿瘤免疫反应，并为免疫检查点阻断（ICB）疗法提供了新的潜在靶点。References: Zhang Y, Guo Y, Liu Z, et al. Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance[J]. Cell, 2025.
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