这篇文章详细描述了一项利用基质辅助激光解吸/电离成像质谱 (MALDI-IMS) 和深度学习人工智能 (MET-MAP) 的综合实验-计算工作流程，以绘制小鼠肝脏和小肠中的空间代谢梯度。研究人员发现，在肝小叶和肠绒毛中，超过 90% 的测量代谢物显示出显著的浓度梯度，并结合同位素示踪来追踪代谢活动的区域变化，例如谷氨酰胺和乳酸在三羧酸（TCA）循环中的贡献。一个关键发现是，膳食糖果糖会导致肝脏中央静脉周围区域的三磷酸腺苷（ATP）耗尽，突出了这种定位如何影响代谢紊乱。总的来说，这项工作提供了关于肠道和肝脏代谢组织的基础知识，并确定了果糖引起的焦点代谢异常。References: Samarah L Z, Zheng C, Xing X, et al. Spatial metabolic gradients in the liver and small intestine[J]. Nature, 2025: 1-9.
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