这篇文章详细介绍了对源自人类肠道的温和噬菌体进行分离、工程改造和生态学研究。研究人员表征了 134 种可诱导的前噬菌体，这些噬菌体来自 252 种人类肠道细菌分离株，旨在增强对噬菌体-宿主相互作用的功能理解。值得注意的是，实验发现仅有少数计算预测的前噬菌体可以被诱导，并且在与人类结肠细胞（Caco2）共培养的合成微生物组中，人类宿主相关产物可能作为前噬菌体诱导剂。研究还表明，多溶源性很常见，并且非功能性整合和切除基因中的突变是前噬菌体失活并被困于宿主基因组内的遗传途径。总而言之，该研究强调了培养技术、实验验证和基因组学在理解肠道微生物组中温和噬菌体的生物学和功能方面的重要性。References: Dahlman S, Avellaneda-Franco L, Rutten E L, et al. Isolation, engineering and ecology of temperate phages from the human gut[J]. Nature, 2025: 1-8.
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