这份研究主要关注成人弥漫性胶质瘤（一种常见的脑肿瘤）中的三级淋巴结构 (TLSs)，传统上认为胶质瘤属于“免疫冷”肿瘤。作者在 15% 的胶质瘤中发现了这些结构，并根据其细胞组成和免疫活动将其分为三种亚型：T-low-TLS、B:T-TLS 和PC-TLS。研究发现，具有成熟功能性 TLS（特别是 B:T-TLS 和 PC-TLS）的患者的总生存期有所改善，表明这些结构在胶质瘤的适应性免疫激活中发挥着关键作用。该研究利用多模式空间分析（包括空间转录组学和蛋白质组学）来探究 TLS 的功能特征，例如克隆性淋巴细胞扩增和浆细胞形成，并提出 TLS 成熟度可以作为预测免疫治疗敏感性的生物标志物。References: Cakmak P, Lun J H, Singh A, et al. Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures[J]. Immunity, 2025.
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