这篇文章通过结合单细胞和空间转录组学技术，详细阐述了人类早期心脏发育过程中的时空基因表达和细胞动态。研究人员创建了一个高分辨率的人类心脏发育转录组图谱，揭示了从妊娠后第5.5周到第14周期间，31种粗粒度和72种细粒度细胞状态的空间排列，以及它们在不同功能生态位中的组织。该研究提供了关于心脏起搏传导系统、心脏瓣膜和心房隔膜形成的关键见解，并首次在空间上描述了胎儿心脏中的嗜铬细胞群。这项工作为探索人类心脏发育的细胞和分子蓝图提供了一个开放获取的交互式资源，有助于理解先天性心脏病的遗传病因。References: Lázár E, Mauron R, Andrusivová Ž, et al. Spatiotemporal gene expression and cellular dynamics of the developing human heart[J]. Nature Genetics, 2025: 1-16.
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