该文章主要讨论了“冷肿瘤”（“cold” tumors）的内在机制及其转化为“热肿瘤”（“hot” tumors）的治疗策略。文章详细阐述了“冷肿瘤”逃避免疫系统检测和破坏的三大核心机制：伪装（Camouflage），即通过缺陷的抗原呈递和免疫细胞浸润障碍实现；胁迫（Coercion），即通过免疫抑制细胞网络和代谢重编程等方式压制免疫功能；以及细胞保护（Cytoprotection），即通过抵抗炎性细胞死亡信号来实现免疫逃逸。最后，文章综述了将“冷肿瘤”转化为“热肿瘤”的创新疗法，包括生物材料递送系统、靶向代谢和神经-免疫轴的策略，以及促进炎性细胞死亡的方法，旨在增强癌症免疫治疗的有效性。References: Liu Y T, Wang Y L, Wang S, et al. Turning cold tumors into hot tumors to ignite immunotherapy[J]. Molecular Cancer, 2025, 24(1): 254.
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