这篇文章探讨了一种治疗高危神经母细胞瘤的联合策略，该疾病是一种致命的儿童癌症。作者们发现，结合使用二氟甲基鸟氨酸（DFMO）药物（一种多胺生物合成抑制剂）和不含脯氨酸及精氨酸的饮食，能显著增强小鼠模型中的抗肿瘤活性和生存率。这种联合干预通过有效耗竭鸟氨酸（一种多胺前体），导致核糖体停滞，特别是针对那些第三位碱基为腺苷的密码子。由于这些受影响的密码子在细胞周期基因中富集，而在神经元分化基因中含量较低，因此治疗选择性地抑制了肿瘤的增殖程序并诱导了肿瘤的神经元分化。最终，这项研究提出了一种新的机制，即代谢限制可通过密码子特异性翻译重新布线，为激活儿科癌症的分化提供了靶向途径。References: Cherkaoui S, Turn C S, Yuan Y, et al. Reprogramming neuroblastoma by diet-enhanced polyamine depletion[J]. Nature, 2025: 1-9.
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