这篇文章主要探讨了神经相关巨噬细胞 (NAMs) 在脂肪组织稳态和年龄相关炎症（“炎症衰老”）中的作用。研究人员使用单细胞测序和小鼠模型，详细描绘了脂肪组织巨噬细胞 (ATMs) 的多样性，发现随着衰老，NAMs（具体为 CD169+CD11c− 子集）的数量会减少，同时出现一种新的 CD38+ 年龄相关巨噬细胞 (AAMs) 亚群。通过移除 NAMs，作者证明了这种细胞对于调节脂肪分解和抑制衰老引起的炎症至关重要，揭示了脂肪组织功能衰退和炎症之间的神经免疫联系。References: Gonzalez-Hurtado E, Leveau C, Li K, et al. Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation[J]. Nature Aging, 2025: 1-16.
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