这篇研究文章探讨了人类脑癌（如胶质母细胞瘤，GBM）如何重新调整葡萄糖代谢以促进其侵袭性生长。作者们通过向患者和模型小鼠输注标记的葡萄糖，并结合定量代谢通量分析（MFA），发现与正常皮层组织不同，GBM减少了葡萄糖碳在三羧酸循环（TCA）氧化和神经递质合成等生理过程中的使用。相反，肿瘤将葡萄糖衍生碳优先用于核苷酸和NAD的合成，从而满足细胞增殖需求，并且依赖环境中的丝氨酸作为替代碳源。通过限制饮食中的丝氨酸/甘氨酸，研究人员成功地改变了小鼠GBM的代谢，减缓了肿瘤生长并增强了标准化疗和放疗的疗效，提出了潜在的代谢靶向治疗策略。References: Scott A J, Mittal A, Meghdadi B, et al. Rewiring of cortical glucose metabolism fuels human brain cancer growth[J]. Nature, 2025: 1-10.
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