这篇研究文章系统性地评估了四种高通量、亚细胞分辨率的空间转录组学平台，包括 Stereo-seq v1.3、Visium HD FFPE、CosMx 6K 和 Xenium 5K。研究人员使用结肠腺癌、肝细胞癌和卵巢癌的系列组织切片生成了统一的多组学数据集，并通过 CODEX 蛋白组学分析和单细胞 RNA 测序建立了参考“金标准”。评估内容涵盖了捕获灵敏度、细胞分割准确性、细胞类型注释以及空间聚类等关键性能指标。研究结果为这些快速发展的技术提供了实际的指导，并创建了一个名为 SPATCH 的公开网络服务器，供研究人员访问和探索这些全面的数据集。References: Ren P, Zhang R, Wang Y, et al. Systematic benchmarking of high-throughput subcellular spatial transcriptomics platforms across human tumors[J]. Nature Communications, 2025, 16(1): 9232.
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