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聊聊Sci

258-NextBrain:概率性人脑组织学图谱

23 Nov 2025

Description

这篇文章介绍了NextBrain的开发,这是一个概率性人类脑组织学图谱,旨在改善磁共振成像(MRI)的脑区分割和分析。研究人员利用 人工智能 方法对来自五个脑半球的近 10,000 个组织学切片进行三维对齐和重建,并为333个感兴趣区域(ROI) 生成了细致的概率标签。NextBrain 及其附带的 贝叶斯分割工具 能够实现比现有方法更高精度的体素级分析,这在超高分辨率离体MRI分割和体内MRI对阿尔茨海默病等疾病的细粒度研究中得到了应用。最终,NextBrain的数据、图谱和工具被公开,旨在推动全球研究人员对人脑健康与疾病的理解。References: Casamitjana A, Mancini M, Robinson E, et al. A probabilistic histological atlas of the human brain for MRI segmentation[J]. Nature, 2025: 1-8.

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