这篇文章对哺乳动物脑部端脑中的 GABA能神经元 进行了全面且深入的转录组学和空间分析。研究人员利用大量的单细胞转录组数据，构建了一个分层的细胞类型分类系统（分类、亚类、超类型和集群），涵盖了小鼠端脑所有区域的 GABA能神经元。此外，研究还追踪了这些神经元的发育起源和轨迹，发现细胞类型关系反映了空间位置和胚胎发育起源，并且许多相关细胞类型通过长距离迁移分散在不同脑区。研究结果揭示了空间基因表达梯度，以及皮层和纹状体神经元与隔膜、视前区和苍白球神经元在出生后分化时间上的显著差异，为理解端脑 GABA能回路的组织提供了基础性参考。References: van Velthoven C T J, Gao Y, Kunst M, et al. Transcriptomic and spatial organization of telencephalic GABAergic neurons[J]. Nature, 2025, 647(8088): 143-156.
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