欢迎收听科研喵播客，使用AI读文献，祝你效率百倍，快来labcat.com.cn下载吧。最新的医学研究揭示了腹腔内化疗对抗腹膜转移瘤的潜力。面对卵巢、结肠、胰腺和胃癌等癌症的腹膜转移，传统化疗效果有限。而腹腔内化疗能提供高浓度药物，增强疗效，减少全身毒性。研究探讨了三种腹腔内化疗方法：热腹腔化疗(HIPEC)、加压腹腔气溶胶化疗(PIPAC)和基于导管的腹腔化疗(CBIP)，它们在药物动力学方面各有优势。研究还评估了常用药物，如铂类药物、紫杉醇和新型纳米颗粒制剂的药动学数据。虽然药动学原理支持腹腔内化疗，但仍需等待临床试验结果。纳米颗粒和控释系统的创新有望提高药物保留和靶向输送，减少全身毒性。持续探索这些领域，优化化疗方案，对提高患者疗效、优化治疗策略至关重要。
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