欢迎收听科研喵播客，用AI读文献，让你的科研效率百倍提升。现在，访问labcat.com.cn下载吧！ 在最新的《Journal of nanobiotechnology》上，一项突破性研究发现了一种名为LT@MnO@MON-HA（LMMH）的新型纳米药物，它能够激活肿瘤微环境中的cGAS-STING途径，并干扰肿瘤代谢，从而增强抗肿瘤疗效。这种纳米药物由锰氧化物纳米颗粒为核心，有机介孔二氧化硅为外层，内含线粒体糖酵解抑制剂LT，并以透明质酸精确靶向肿瘤。LMMH在肿瘤微环境中分解，释放LT和Mn(2+)，其中LT扰乱线粒体代谢，增加活性氧，而Mn(2+)增强化学动力学疗法。此外，LMMH还能耗尽肿瘤微环境中的谷胱甘肽，进一步增强疗效，并激活全身免疫反应。这一发现为调节肿瘤微环境和代谢，提高免疫疗效提供了新思路。不要错过这一激动人心的研究进展！
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