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欢迎来到我们的医学播客，科研喵使用AI读文献，祝你效率百倍，现在访问labcat.com.cn下载。最新研究发现，非肝硬化患者中的肝细胞癌（HCC）发病率在发达国家显著上升，尤其是与代谢功能障碍相关的脂肪肝病（MASLD）有关。尽管肝硬化是HCC的主要风险因素，但约80%的HCC病例发生在肝硬化患者中，而非肝硬化HCC患者的数量却不断增加。这一现象突显了对非肝硬化HCC患者筛查和临床管理指南的迫切需求，因为目前的治疗策略通常是基于肝硬化患者的研究，这可能导致对非肝硬化患者治疗有效性、生存结果和病因变异的知识空白。这项研究的发现对于改进非肝硬化HCC患者的诊断和治疗策略至关重要。
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