欢迎收听我们的医学播客，科研喵使用AI读文献，祝你效率百倍，马上访问labcat.com.cn下载。在最新的研究中，专家们深入探讨了HER3在乳腺癌中的关键作用。HER3，作为HER家族中的一个非激酶成员，通过与HER2异源二聚化显著影响乳腺癌的进展，尤其在治疗抗性方面，成为跨亚型治疗的关键靶点。这项研究不仅分析了HER3的分子结构和信号传导路径，还评估了其在肿瘤进展和治疗抗性中的影响，特别是在HER2阳性、激素受体阳性和三阴性亚型中。临床试验显示，HER3过表达在30-50%的病例中出现，而针对HER3的抗体-药物偶联物（ADCs）如patritumab deruxtecan，在试验中显示出巨大潜力。专家们认为，HER3的靶向治疗有望通过新型治疗组合和生物工程创新，成为未来几年日常临床实践的重要组成部分，推动精准肿瘤学的发展。
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